Nutriomics | Nutrition and Obesities: Systemic Approaches

TOPIC 1

Progression of obesity and related complications: role of gut microbiota?

TOPIC 2

Intestine as a key player in metabolic disorders

TOPIC 3

Adipose tissue Remodeling

TOPIC 4

Systems’ biology and data integration (transversal WP)

TOPIC 5

Translating our fundamental research for the benefit of patients.

Define gut microbiota signature in CMD and evaluate the impact of environment (diet and drugs)
Demonstrate causality of CMD microbial signature in the development of CMD or its resolution
Perform interventions:
- - in humans: Metacardis follow-up (development), diet or bariatric surgery (reversal)
  - in mice: gut microbiota transfer experiments (induce CMD or its reversal)

The digestive tract is vulnerable to modifications coming from both external factors such as food and microbiota, and internal factors such as the immune system. As a result, the adaptations that occur within the gut can have significant effects on immune function, the maintenance of epithelial cell balance, and essential organs that regulate energy balance.

Understand WAT fibrosis : Explore the role of progenitors
Characterize WAT senescence :
- Evaluate inappropriate turnover of subcellular components (Lysosomal degradation)
- Examine PG as gut-derived signaling modulators in AT remodeling

Our aim is to innovate cutting-edge tools for data analysis, physiological status prediction, and visualisation in metabolic diseases . We will employ a range of techniques, including statistical inferences, machine learning, and mechanistic approaches utilizing dynamical systems. This work package is closely integrated with other work packages that generate large-scale data.

Two main axes

Develop innovative diagnosis and predictive factors/tools:
Develop novel approaches for therapy with personalized medicine

Latest Publications

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

2023-03-27T14:29:52+02:00December 10, 2022|Comments Off on Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

Gut 71, 12 (2022). doi: 10.1136/gutjnl-2021-325753
Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome's functional composition...

Microbiome and metabolome features of the cardiometabolic disease spectrum

2023-03-27T14:30:14+02:00February 17, 2022|Comments Off on Microbiome and metabolome features of the cardiometabolic disease spectrum

Nat Med. 2022 Feb;28(2):303-314. doi: 10.1038/s41591-022-01688-4
Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid conditions, or polypharmacy....

Adipose Tissue Fibrosis in Obesity: Etiology and Challenges

2023-03-27T14:21:58+02:00February 10, 2022|Comments Off on Adipose Tissue Fibrosis in Obesity: Etiology and Challenges

Annu Rev Physiol. 2022 Feb 10;84:135-155. doi: 10.1146/annurev-physiol-060721-092930
Obesity is a chronic and progressive process affecting whole-body energy balance and is associated with comorbidity development...

The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass

2023-03-27T14:30:41+02:00January 11, 2022|Comments Off on The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass

Gut Microbes 14,1 (2022). doi: 10.1080/19490976.2022.2050635
Roux-en-Y gastric bypass (RYGB) is efficient at inducing drastic albeit variable weight loss and type-2 diabetes (T2D) improvements in patients with severe obesity and T2D...

Intestinal alteration of α-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission

2023-03-27T14:29:40+02:00March 21, 2021|Comments Off on Intestinal alteration of α-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission

Am J Physiol Endocrinol Metab 321, 3 (2021). doi: 10.1152/ajpendo.00071.2021
Carbohydrates and sweeteners are detected by the sweet taste receptor in enteroendocrine cells (EECs). This receptor is coupled to the gustducin G-protein, which α-subunit is encoded by GNAT3 gene...

Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies

2023-03-27T14:28:00+02:00January 21, 2021|Comments Off on Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies

J. Gastroenterol. 160, 2 (2021). doi: 10.1053/j.gastro.2020.10.057
Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice...

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

2020-11-18T17:32:43+01:00November 18, 2020|Comments Off on Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Nat Commun 11, 5881 (2020). https://doi.org/10.1038/s41467-020-19589-w
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism...

Weight Loss After Sleeve Gastrectomy: Does Type 2 Diabetes Status Impact Weight and Body Composition Trajectories?

2020-11-18T15:49:37+01:00November 4, 2020|Comments Off on Weight Loss After Sleeve Gastrectomy: Does Type 2 Diabetes Status Impact Weight and Body Composition Trajectories?

Obes Surg. 2020 Nov 4. doi: 10.1007/s11695-020-05075-1.
Sleeve gastrectomy (SG), the most frequently performed bariatric procedure, induces marked weight-loss, but with high inter-individual variability...