Gut 71, 12 (2022). doi: 10.1136/gutjnl-2021-325753
Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome's functional composition...
Nat Med. 2022 Feb;28(2):303-314. doi: 10.1038/s41591-022-01688-4
Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid conditions, or polypharmacy....
Annu Rev Physiol. 2022 Feb 10;84:135-155. doi: 10.1146/annurev-physiol-060721-092930
Obesity is a chronic and progressive process affecting whole-body energy balance and is associated with comorbidity development...
Gut Microbes 14,1 (2022). doi: 10.1080/19490976.2022.2050635
Roux-en-Y gastric bypass (RYGB) is efficient at inducing drastic albeit variable weight loss and type-2 diabetes (T2D) improvements in patients with severe obesity and T2D...
Am J Physiol Endocrinol Metab 321, 3 (2021). doi: 10.1152/ajpendo.00071.2021
Carbohydrates and sweeteners are detected by the sweet taste receptor in enteroendocrine cells (EECs). This receptor is coupled to the gustducin G-protein, which α-subunit is encoded by GNAT3 gene...
J. Gastroenterol. 160, 2 (2021). doi: 10.1053/j.gastro.2020.10.057
Changes in the intestinal microbiome have been associated with obesity and type 2 diabetes, in epidemiological studies and studies of the effects of fecal transfer in germ-free mice...
Nat Commun 11, 5881 (2020). https://doi.org/10.1038/s41467-020-19589-w
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism...
Obes Surg. 2020 Nov 4. doi: 10.1007/s11695-020-05075-1.
Sleeve gastrectomy (SG), the most frequently performed bariatric procedure, induces marked weight-loss, but with high inter-individual variability...
Diabetes. 2020 Nov 2:db200578. doi: 10.2337/db20-0578
Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes is unclear.
Lancet Diabetes Endocrinol. 2020 Oct 30:S2213-8587(20)30364-8.
The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused by biallelic variants in genes that affect the MC4R pathway...
Diabetologia. 2020 Oct 30. doi: 10.1007/s00125-020-05307-0.
Altered adipose tissue secretory profile contributes to insulin resistance and type 2 diabetes in obesity. Preclinical studies have identified senescent cells as a cellular source of proinflammatory factors in adipose tissue of obese mice.
PLoS Genet. 2020 Oct 12;16(10):e1008718. doi: 10.1371/journal.pgen.1008718. eCollection 2020 Oct
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown.
Int J Obes. 2020 Oct 9. doi: 10.1038/s41366-020-00694-1.
Altered enteroendocrine cell (EEC) function in obesity and type 2 diabetes is not fully understood. Understanding the transcriptional program that controls EEC differentiation is important because some EEC types harbor significant therapeutic potential for type 2 diabetes.
Diabetes. 2020 Sep 29:db200647. doi: 10.2337/db20-0647.
Obesity is a major risk factor for insulin resistance (IR) and its attendant complications. The pathogenic mechanisms linking them remain poorly understood, partly due to a lack of intermediary monogenic human phenotypes.
Obesity (Silver Spring). 2020 Sep 1. doi: 10.1002/oby.23026.
Obesity is a major risk factor of severe forms of COVID‐19 but little is known about the post bariatric surgery (BS) setting...
Gastroenterology. 2020 Aug 26:S0016-5085(20)35111-8. doi: 10.1053/j.gastro.2020.08.041.
We evaluated the efficacy and safety of diet-modulated autologous fecal microbiota transplantation (aFMT) for treatment of weight regain after the weight-loss phase....
EBioMedicine. 2020 Aug;58:102895. doi: 10.1016/j.ebiom.2020.102895.
Bariatric surgery is an effective treatment for type 2 diabetes. Early post-surgical enhancement of insulin secretion is key for diabetes remission...
Sci Rep. 2020 Jun 15;10(1):9624. doi: 10.1038/s41598-020-66598-2.
Type 2 diabetes mellitus (T2DM) drastically affects the population of Middle East countries with an ever-increasing number of overweight and obese individuals. The precise links between T2DM and gut microbiome composition remain elusive in these populations...
Obesity (Silver Spring). 2020 Aug;28(8):1386-1396. doi: 10.1002/oby.22806. Epub 2020 Jun 10.
This review details the proceedings of a Pennington Biomedical scientific symposium titled, “What Should I Eat and Why? The Environmental, Genetic, and Behavioral Determinants of Food Choice"...
Obesity (Silver Spring). 2020 Sep;28(9):1584-1585. doi: 10.1002/oby.22924.
Despite repeated efforts by the international scientific community, academic societies, and the combined actions of patient associations, public authorities have difficulties in admitting that obesity is not just a risk factor but a disease...