J. Clin. Endocrinol. Metab. 2016 Jun;101(6):2578-87
CONTEXT: Collagen accumulation around adipocytes and vessels (ie, pericellular fibrosis) is a hallmark of obese adipose tissue ass...
BMJ Open Gastroenterol 2016;3(1):e000075
BACKGROUND: Type-2 diabetes mellitus (T2DM) is a risk factor for progressive non-alcoholic fatty liver disease (NAFLD). Drugs comm...
Sci Rep 2016 Apr;6:24618
Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (...
Obes Surg 2016 Apr;26(4):785-96
BACKGROUND: Roux-en-Y gastric bypass (GBP) and sleeve gastrectomy (SG) have increased dramatically, potentially increasing the pre...
PLoS ONE 2016;11(2):e0149588
BACKGROUND: The number of morbidly obese patients undergoing bariatric surgery (BS) has increased dramatically in recent years. Th...
Gut 2016 Mar;65(3):426-36
OBJECTIVE: Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut...
J. Clin. Endocrinol. Metab. 2016 Jan;101(1):293-304
CONTEXT: Extracellular matrix (ECM) in sc adipose tissue (scAT) undergoes pathological remodeling during obesity. However, its evo...
FASEB J. 2016 Jan;30(1):241-51
In mice, nutritional supplementation with the trans-10,cis-12 isomer of linoleic acid (t10,c12-CLA) promotes lipoatrophy, hyperinsulinemia, and mac...
Cell Metab. 2015 Dec;22(6):1045-58
Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants MCs toward anti-infl...
Endocrinology 2015 Nov;156(11):4047-58
Prior studies demonstrated increased plasma IgE in diabetic patients, but the direct participation of IgE in diabetes or obesity remains unknown. T...
PLoS ONE 2015;10(10):e0138880
BACKGROUND AND OBJECTIVES: Identification of new targets for metabolic diseases treatment or prevention is required. In this conte...
EBioMedicine 2015 Aug;2(8):968-84
UNLABELLED: Gut microbiota has been implicated as a pivotal contributing factor in diet-related obesity; however, its role in deve...
PLoS ONE 2015;10(9):e0138646
BACKGROUND: Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.OBJECTIVE...
Diabetes 2015 Oct;64(10):3452-63
Adipose tissue dysfunction in obesity has been linked to low-grade inflammation causing insulin resistance. Transcriptomic studies have identified ...
Cardiovasc. Res. 2015 Oct;108(1):62-73
AIMS: Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, a...
PLoS ONE 2015;10(9):e0134683
In large-scale systems biology applications, features are structured in hidden functional categories whose predictive power is identical. Feature s...
Diabetes 2015 Sep;64(9):3121-34
Inflammation and lipid accumulation are hallmarks of muscular pathologies resulting from metabolic diseases such as obesity and type 2 diabetes. Du...
Cell Metab. 2015 Aug;22(2):320-31
The human gut microbiome is known to be associated with various human disorders, but a major challenge is to go beyond association studies and eluc...
J. Gastroenterol. Hepatol. 2015 Aug;30(8):1293-300
BACKGROUND AND AIMS: Macrophages play an important role in non-alcoholic fatty liver disease (NAFLD). Soluble CD163 (sCD163) is a ...
J Magn Reson Imaging 2015 Aug;42(2):379-89
BACKGROUND: Left atrium (LA) volumes and function are predictors of cardiovascular events. Because LA function cannot be assessed ...