Cell Metab. 2015 Jul;22(1):113-24
In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut is a very large lymphoid tissue, inflammation in the ...
J Nutr Sci 2015;4:e22
The enterohormone glucagon-like peptide-1 (GLP-1) is required to amplify glucose-induced insulin secretion that facilitates peripheral glucose util...
Nat. Med. 2015 Jun;21(6):610-8
Accumulation of visceral adipose tissue correlates with elevated inflammation and increased risk of metabolic diseases. However, little is known ab...
J. Clin. Endocrinol. Metab. 2015 May;100(5):E757-66
CONTEXT: Infrequent mutations have been reported in the leptin receptor (LEPR) gene in humans with morbid obesity and endocrine di...
PLoS ONE 2015;10(5):e0125718
BACKGROUND: Bariatric surgery is associated to improvements in obesity-associated comorbidities thought to be mediated by a decrea...
J. Immunol. 2015 Apr;194(8):3917-23
Three subpopulations of circulating monocytes have been described: CD14(2+)CD16(-) (classical monocytes [CM]), CD14(2+)CD16(+) (intermediate monocy...
Eur. Heart J. 2015 Apr;36(13):795-805a
AIMS: Recent studies have reported a relationship between the abundance of epicardial adipose tissue (EAT) and the risk of cardiov...
J. Clin. Invest. 2015 Apr;125(4):1752-62
Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mu...
J. Hepatol. 2015 Apr;62(4):905-12
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning...
Diabetes 2015 Mar;64(3):840-55
The role of the ATP-binding cassette G1 (ABCG1) transporter in human pathophysiology is still largely unknown. Indeed, beyond its role in mediating...
Endocrinology 2015 Mar;156(3):789-801
During obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we ana...
J Am Heart Assoc 2015 Jan;4(1):e001266
BACKGROUND: Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation thro...
JAMA Pediatr 2014 Dec;168(12):1122-30
IMPORTANCE: Patterns of body size and body composition associated with genetic obesity susceptibility inform the mechanisms that i...
Diabetes 2014 Dec;63(12):4032-44
Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic di...
PLoS ONE 2014;9(10):e109434
BACKGROUND: Associations between dietary patterns, metabolic and inflammatory markers and gut microbiota are yet to be elucidated....
Obes Surg 2014 Nov;24(11):1896-903
BACKGROUND: This study aims to determine the influence of Roux-en-Y gastric bypass (RYGB) on medication-related costs.
J. Clin. Endocrinol. Metab. 2014 Aug;99(8):E1466-70
CONTEXT: Adipocyte volume has been associated with insulin resistance and type 2 diabetes.OBJECTIVE: Our p...
Diabetologia 2014 Aug;57(8):1674-83
AIMS/HYPOTHESIS: Cathepsin S (CatS) belongs to a family of proteases that have been implicated in several disease processes. We pr...
Nat Commun 2014 Jun;5:4309
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition, strongly associated with the metabolic syndrome, that can lead to pr...
Int J Obes (Lond) 2014 Jun;38(6):883-5
Melanocortin-4 receptor (MC4R) gene mutations are involved in the leptin-melanocortin pathways that control food intake. The effect of these mutati...