EBioMedicine 2015 Aug;2(8):968-84
UNLABELLED: Gut microbiota has been implicated as a pivotal contributing factor in diet-related obesity; however, its role in deve...
PLoS ONE 2015;10(9):e0138646
BACKGROUND: Preventing or slowing the progression of prediabetes to diabetes is a major therapeutic issue.OBJECTIVE...
Diabetes 2015 Oct;64(10):3452-63
Adipose tissue dysfunction in obesity has been linked to low-grade inflammation causing insulin resistance. Transcriptomic studies have identified ...
Cardiovasc. Res. 2015 Oct;108(1):62-73
AIMS: Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, a...
PLoS ONE 2015;10(9):e0134683
In large-scale systems biology applications, features are structured in hidden functional categories whose predictive power is identical. Feature s...
Diabetes 2015 Sep;64(9):3121-34
Inflammation and lipid accumulation are hallmarks of muscular pathologies resulting from metabolic diseases such as obesity and type 2 diabetes. Du...
Cell Metab. 2015 Aug;22(2):320-31
The human gut microbiome is known to be associated with various human disorders, but a major challenge is to go beyond association studies and eluc...
J. Gastroenterol. Hepatol. 2015 Aug;30(8):1293-300
BACKGROUND AND AIMS: Macrophages play an important role in non-alcoholic fatty liver disease (NAFLD). Soluble CD163 (sCD163) is a ...
J Magn Reson Imaging 2015 Aug;42(2):379-89
BACKGROUND: Left atrium (LA) volumes and function are predictors of cardiovascular events. Because LA function cannot be assessed ...
J Nutr Sci 2015;4:e22
The enterohormone glucagon-like peptide-1 (GLP-1) is required to amplify glucose-induced insulin secretion that facilitates peripheral glucose util...
Cell Metab. 2015 Jul;22(1):113-24
In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut is a very large lymphoid tissue, inflammation in the ...
Nat. Med. 2015 Jun;21(6):610-8
Accumulation of visceral adipose tissue correlates with elevated inflammation and increased risk of metabolic diseases. However, little is known ab...
J. Clin. Endocrinol. Metab. 2015 May;100(5):E757-66
CONTEXT: Infrequent mutations have been reported in the leptin receptor (LEPR) gene in humans with morbid obesity and endocrine di...
PLoS ONE 2015;10(5):e0125718
BACKGROUND: Bariatric surgery is associated to improvements in obesity-associated comorbidities thought to be mediated by a decrea...
J. Immunol. 2015 Apr;194(8):3917-23
Three subpopulations of circulating monocytes have been described: CD14(2+)CD16(-) (classical monocytes [CM]), CD14(2+)CD16(+) (intermediate monocy...
J. Clin. Invest. 2015 Apr;125(4):1752-62
Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mu...
Eur. Heart J. 2015 Apr;36(13):795-805a
AIMS: Recent studies have reported a relationship between the abundance of epicardial adipose tissue (EAT) and the risk of cardiov...
J. Hepatol. 2015 Apr;62(4):905-12
BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning...
Diabetes 2015 Mar;64(3):840-55
The role of the ATP-binding cassette G1 (ABCG1) transporter in human pathophysiology is still largely unknown. Indeed, beyond its role in mediating...
Endocrinology 2015 Mar;156(3):789-801
During obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we ana...